Pharmaceutical Intermediates Alamanuia Aotelega

Vaila'au vavalo
O mea e taʻua o vailaʻau faʻatauvaʻa o mea moni o vailaʻau mataʻutia poʻo vailaʻau vailaʻau e manaʻomia ona faʻaaogaina i le faʻaogaina o vailaʻau. O nei vailaʻau vailaʻau e mafai ona gaosia i vailaʻau faʻapitoa masani e aunoa ma le mauaina o se laisene gaosiga o vailaʻau, ma e mafai ona faʻaaogaina i le tuʻufaʻatasia ma le gaosiga o vailaʻau pe afai o faʻamatalaga faʻapitoa e fetaui ma tulaga manaʻomia. E ui lava o le tuʻufaʻatasiga o vailaʻau faʻapitoa e pa'ū foi i lalo o le vailaʻau vailaʻau, o manaʻoga e sili atu le faʻamalosi nai lo mea mo oloa vailaʻau masani. O gaosiga o vailaʻau faʻamaeʻaina ma API e manaʻomia le taliaina o le GMP faʻamaonia, ae e le o faia e le au gaosi mea faʻapitoa, aua o loʻo naʻo le tuʻufaʻatasia ma le gaosiga o vailaʻau faʻasolosolo, o mea pito sili ona taua ma pito i lalo i le gaosiga o fualaau faasaina, ma e le mafai ona ua taʻua o fualaau faasaina, o lea latou te le manaʻomia le GMP tusipasi, lea e faʻaititia ai foʻi le avanoa e ulufale ai mo tagata gaosi oloa.

Alamanuia tau vailaau
Kamupani vaila'au o lo'o gaosia ma fa'agaoioia mea fa'aletino/inorganic intermediates po'o APIs mo kamupani vaila'au mo le gaosiga o vaila'au fa'amae'aina e ala i vaila'au po'o meaola fa'aola e tusa ai ma tulaga lelei. O iinei o loʻo vaevaeina ai vailaʻau faʻapitoa i ni vaega laiti se lua CMO ma CRO.

CMO
Fa'alapotopotoga Gaosi Konekarate o lo'o fa'atatau i se fa'alāpotopotoga gaosiga fa'akonekarate, o lona uiga e tu'uina atu e le kamupani vaila'au le fa'agasologa o gaosiga i se paaga. Ole filifili pisinisi ole alamanuia CMO pharmaceutical e masani lava ona amata i mea faʻapitoa tau vailaʻau. Kamupani i totonu o le alamanuia e manaʻomia le faʻaputuina o mea faʻapitoa kemisi ma faʻaogaina i mea faʻapitoa mo vailaʻau faʻapitoa, ona faʻaogaina lea i mea amata API, cGMP intermediates, API ma faʻavae. I le taimi nei, o kamupani fa'ale-malo tetele o lo'o taumafai e fa'atūina faiga fa'apa'aga mo se taimi umi ma se vaega to'aitiiti o fa'atau oloa autu, ma o le olaola o kamupani i totonu o lenei alamanuia e tele lava ina iloa e ala ia latou pa'aga.

CRO
Konekarate (Clinical) Fa'alapotopotoga Su'esu'e e fa'atatau i se fa'alapotopotoga su'esu'e fa'akonekarate, lea e fa'atau atu e kamupani vaila'au le vaega su'esu'e i se paaga. I le taimi nei, o le alamanuia o loʻo faʻavae i luga o le gaosiga masani, R&D masani ma suʻesuʻega konekarate ma faʻatauga. E tusa lava po o le a le auala, pe o le vailaʻau vaʻaia o se oloa fou pe leai, o le tauvaga autu a le kamupani o loʻo faʻamasinoina pea e le R & D tekinolosi o le elemene muamua, lea o loʻo faʻaalia i lalo ifo o tagata faʻatau poʻo paaga a le kamupani.

Fuafuaga tau maketi oloa tau vailaau
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(Ata mai le Qilu Securities)

Alamanuia filifili ole alamanuia intermediates vailaau
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(Ata mai Saina Alamanuia Fa'amatalaga Fa'amatalaga)

Fa'avasegaga o vaila'au tu'ufa'atasi
E mafai ona vaevaeina vailaʻau vaʻaia i ni vaega tetele e tusa ai ma le faʻaogaina o fanua, e pei o mea vavalo mo vailaʻau faʻamaʻi, vailaʻau mo vailaʻau faʻamaʻi ma analgesic, intermediates mo vailaʻau cardiovascular system ma vailaʻau mo vailaʻau faʻamaʻi mo le kanesa. E tele ituaiga o vailaʻau faʻapitoa, e pei o le imidazole, furan, phenolic intermediates, aromatic intermediates, pyrrole, pyridine, biochemical reagents, sulfur-containing, nitrogen-containing, halogen compounds, heterocyclic compounds, starch, mannitol, microcrystalline cellulose, , dextrin, ethylene glycol, suka paʻu, masima inorganic, ethanol intermediates, stearate, amino acids, ethanolamine, masima potassium, masima sodium ma isi intermediates, ma isi.
Va'aiga lautele o le atina'eina o le alamanuia tau vailaau i Saina
E tusa ai ma le IMS Health Incorporated, mai le 2010 i le 2013, o le maketi o vailaʻau i le lalolagi atoa na tumau pea le tuputupu aʻe, mai le US $ 793.6 piliona i le 2010 i le US $ 899.3 piliona i le 2013, faʻatasi ai ma le maketi o vailaʻau o loʻo faʻaalia vave le tuputupu aʻe mai le 2014, e mafua mai i le maketi a Amerika. . Faʻatasi ai ma le CAGR o le 6.14% mai le 2010-2015, o loʻo faʻamoemoeina le maketi o vailaʻau faʻavaomalo e ulufale atu i se taamilosaga faʻagesegese mai le 2015-2019. Ae ui i lea, talu ai o vailaʻau o loʻo i ai le manaʻoga malosi, o le faʻatupulaia o tupe e faʻamoemoe e matua malosi i le lumanaʻi, ma le maketi o le lalolagi mo vailaʻau e latalata i le US $ 1.22 miliona i le 2019.
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(Ata mai le IMS Health Incorporated)
I le taimi nei, faʻatasi ai ma le toe faʻaleleia o fale gaosi oloa o kamupani faʻapitoa faʻatekonolosi tele, o le fesiitaiga o gaosiga faʻavaomalo ma le faʻaleleia atili o le vaeluaga faʻavaomalo o galuega, ua avea Saina ma se tulaga taua tele gaosiga i le vaeluaga o le lalolagi o galuega i le falemaʻi. Ole alamanuia ole vaila'au ole vaila'au a Saina ua fausia se faiga e matua atoatoa mai su'esu'ega ma atina'e ile gaosiga ma fa'atau. Mai le atinaʻeina o vailaʻau faʻatauvaʻa i le lalolagi, o le tulaga lautele o tekinolosi faʻagasologa o Saina o loʻo maualalo pea, o se numera tele o vailaʻau faʻasolosolo ma pateni vailaʻau fou o loʻo lagolagoina pisinisi faʻatauvaʻa e laʻititi laʻititi, o loʻo i le tulaga o le atinaʻeina o le fausaga o oloa faʻaleleia ma le faʻaleleia. .
Le tau o le gaosiga o vailaʻau vailaʻau faʻatekonolosi i Saina mai le 2011 i le 2015
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(Ata mai Saina Business Industry Research Institute)
I le 2011-2015, fa'atuputeleina le gaosiga o vaila'au vaila'au a Saina i lea tausaga ma lea tausaga, i le 2013, o le gaosiga o vaila'au vaila'au a Saina e 568,300 tone, auina atu i fafo 65,700 tone, i le 2015 o Saina e uiga i vaila'au vaila'au intermediate606.
2011-2015 Saina vaila'au vaila'au vaila'au intermediates alamanuia gaosiga fuainumera
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(Ata mai le China Merchant Industry Research Institute)
O le tuʻuina atu o vailaʻau faʻapitoa i Saina e sili atu ona lauiloa nai lo le manaʻoga, ma o le faʻalagolago i le auina atu i fafo o loʻo faasolosolo malie lava. Ae ui i lea, o oloa auina atu i fafo a Saina e tele lava ina taulai atu i oloa tetele e pei o le vaitamini C, penicillin, acetaminophen, citric acid ma ona masima ma esters, ma isi. tau faaopoopo, ma o latou gaosiga tele ua mafua ai le tulaga o le sapalai e sili atu le manaoga i totonu o maketi tau vailaau i totonu o le atunuu. O oloa o lo'o iai fa'atekonolosi fa'atekonolosi e fa'alagolago lava ile fa'aulufale mai.
Mo le puipuiga o vailaʻau vailaʻau amino acid, o le tele o atinaʻe gaosiga i totonu o le atunuʻu o loʻo i ai se ituaiga oloa e tasi ma le le mautu lelei, aemaise lava mo kamupani biopharmaceutical mai fafo e faʻavasega le gaosiga o oloa. E naʻo nisi atinaʻe e iai le malosi o suʻesuʻega ma atinaʻe malosi, fale gaosi oloa ma poto masani i gaosiga tetele e mafai ona maua ni tupe maua maualuga i le tauvaga.
Su'esu'ega ole alamanuia tau vailaau a Saina

1, pharmaceutical intermediates alamanuia faiga masani gaosiga
Muamua, ia auai i le suʻesuʻega a le tagata faʻatau ma le atinaʻeina o vailaʻau fou, lea e manaʻomia ai le R & D centre a le kamupani o loʻo i ai se malosi malosi fou.
Lona lua, i le faʻalauteleina o oloa pailate a le tagata faʻatau, e faʻafeiloaʻi ai le auala faʻagasologa o le gaosiga tele, lea e manaʻomia ai le faʻalauteleina o le faʻainisinia a le kamupani o le oloa ma le mafai ona faʻaauau pea le faʻaleleia atili o le tekinolosi oloa faʻapitoa i se taimi mulimuli ane, ina ia faʻafeiloaʻi manaʻoga o le gaosiga o fua o oloa, faʻaitiitia le tau o le gaosiga ma faʻaleleia le faʻatauvaʻa o le oloa.
Lona tolu, o le eli ma faʻaleleia le faagasologa o oloa i le tulaga o le tele o gaosiga o tagata faʻatau, ina ia ausia tulaga lelei o kamupani mai fafo.

2. O uiga o le fale gaosi oloa a Saina
O le gaosiga o vailaʻau e manaʻomia ai le tele o vailaʻau faʻapitoa, o le tele o ia mea na gaosia muamua e le falemaʻi lava ia, ae faʻatasi ai ma le faʻalolotoina o le vaeluaga o tagata faigaluega ma le alualu i luma o tekinolosi gaosiga, na faʻafeiloaʻi ai e le falemaʻi vailaʻau nisi vailaʻau faʻasalalau i pisinisi vailaʻau. mo le gaosiga. O vailaʻau faʻatauvaʻa o vailaʻau faʻamaʻi lelei, ma o le gaosiga o vailaʻau vailaʻau ua avea ma pisinisi tele i le pisinisi vailaʻau faʻavaomalo. I le taimi nei, e manaʻomia e le falemaʻi vailaʻau a Saina le tusa ma le 2,000 ituaiga o vailaʻau mataʻutia ma mea faʻalavelave i tausaga taʻitasi, ma le manaʻoga e sili atu i le 2.5 miliona tone. Talu ai o le auina atu i fafo o vailaʻau faʻasalalau e le pei o le auina atu i fafo o vailaʻau o le a noatia i le tele o faʻatapulaʻaina i totonu o atunuu o loʻo faʻaulufaleina mai, faʻapea foʻi ma le gaosiga o le lalolagi o vailaʻau faʻasalalau i atunuʻu atinaʻe, o manaʻoga o loʻo i ai nei i le gaosiga o vailaʻau a Saina o vailaʻau mataʻutia ma mea vavalalata e mafai ona fetaui lelei. , na'o se vaega itiiti o le mana'oga e fa'aulufale mai. Ma ona o le tele o punaoa a Saina, o tau o mea mata e maualalo, o loʻo i ai le tele o vailaʻau faʻatauvaʻa ua ausia foi le tele o oloa auina atu i fafo.

I le taimi nei, e manaʻomia e Saina vailaʻau e lagolago ai mea mataʻutia ma mea e sili atu i le 2500 ituaiga, o le manaʻoga faaletausaga na oʻo i le 11.35 miliona tone. Ina ua maeʻa le silia ma le 30 tausaga o atinaʻe, o manaʻoga o gaosiga o vailaʻau a Saina mo vailaʻau mataʻutia ma mea vavalalata ua mafai ona fetaui. O le gaosiga o intermediates i Saina e masani lava i vailaʻau antibacterial ma antipyretic.

I totonu o le alamanuia, e ono uiga o le fale gaosi oloa a Saina: Muamua, o le tele o atinaʻe o pisinisi tumaoti, faʻaogaina fetuutuunai, e le tele le tupe teufaafaigaluega, i le va o le miliona i le tasi pe lua afe miliona yuan; Lona lua, o le fa'afanua fa'afanua o atina'e o lo'o fa'atumauina, aemaise lava i Taizhou, Itumalo o Zhejiang ma Jintan, Itumalo o Jiangsu e avea ma nofoaga tutotonu; Lona tolu, faʻatasi ai ma le faʻalauteleina o le atunuʻu i le puipuiga o le siosiomaga, o le mamafa o atinaʻe e fausia nofoaga mo togafitiga o le siosiomaga o loʻo faʻateleina lona Fa, o le saoasaoa faʻafouina o oloa e vave, ma o le tupe mama o le a pa'ū tele pe a uma le 3 i le 5 tausaga i le maketi, faʻamalosia pisinisi. ia atia'e oloa fou po'o le fa'aleleia atili o le fa'agasologa fa'aauau ina ia maua ai ni tupe mama maualuga; Lona lima, talu ai e sili atu le maualuga o le gaosiga o vailaʻau faʻatauvaʻa nai lo oloa vailaʻau lautele, ma o le gaosiga o le gaosiga e tutusa lava, o le tele ma sili atu o pisinisi laiti vailaʻau e auai i le tulaga o le gaosiga o vailaʻau, e mafua ai le faʻateleina o le tauvaga malosi i le pisinisi lona ono. , pe a faʻatusatusa i le API, o le tupe mama o le gaosiga o mea vavalalata e maualalo, ma o le gaosiga o le gaosiga o le API ma le vailaʻau faʻapitoa e tutusa, o lea o nisi pisinisi e le gata ina maua ai ni mea vavalalata, ae faʻaaoga foi a latou lava mea lelei e amata ai le gaosia o le API. Na faailoa mai e le au atamamai o le gaosiga o vailaau faafomai i le itu o le atinaeina o le API o se tulaga le maalofia. Ae ui i lea, ona o le tasi le faʻaaogaina o le API, e kamupani vailaʻau e iai se aʻafiaga tele, o pisinisi i totonu o le atunuʻu e masani ona atiaʻe oloa ae leai se faʻaogaina o le mea faʻapitoa. O le mea lea, e tatau i tagata gaosi oloa ona faʻavaeina se vaʻaiga tumau tumau ma kamupani vailaʻau, ina ia mautinoa le faʻatauga lelei o oloa.

3, pa puipui ulufale alamanuia
①Papa fa'atau
O lo'o pulea e ni nai kamupani fa'ama'i vaila'au fa'ale-malo. E matua fa'aeteete le aufaipisinisi i la latou filifiliga o kamupani e tu'uina atu auaunaga i fafo ma e masani lava ona umi se taimi e asiasia ai tagata fou. O kamupani CMO Pharmaceutical e manaʻomia ona faʻafetaui mamanu fesoʻotaʻiga a tagata faʻatau eseese, ma e manaʻomia le faia o se vaitaimi umi o iloiloga faifai pea aʻo leʻi mafai ona latou maua le faʻatuatuaga o tagata faʻatau i lalo, ona avea ai lea ma a latou faʻatau autu.
②Papa fa'atekinisi
O le agava'a e tu'uina atu auaunaga fa'aopoopo fa'atekonolosi maualuga o le maatulimanu lea o se kamupani 'au'aunaga i fafo atu o vaila'au. E manaʻomia e kamupani CMO vailaʻau ona talepeina faʻagata faʻatekinisi poʻo poloka i latou auala muamua ma tuʻuina atu auala faʻapitoa mo vailaʻau e faʻaitiitia ai le tau o le gaosiga o vailaʻau. A aunoa ma se taimi umi, maualuga tau tupe faʻafaigaluega i suʻesuʻega ma atinaʻe ma tekinolosi faʻaagaaga, e faigata mo kamupani i fafo atu o le alamanuia ona ulufale moni i le alamanuia.
③Taleni pa pupuni
E faigata mo kamupani CMO ona fausia se R&D fa'atauva ma 'au gaosiga i se taimi pu'upu'u e fa'atūina ai se fa'ata'ita'iga pisinisi e fa'atatau i le cGMP.
④Tulaga fa'atulafonoina pa puipui
O le FDA ma isi lala sooupu faʻatonutonu vailaʻau ua faʻateleina le faʻamalosia o latou manaʻoga lelei, ma o oloa e le pasia le suʻega e le mafai ona ulufale i maketi o atunuʻu faʻaulufale mai.
⑤ Pa puipui fa'alesiosiomaga
O kamupani talavai o lo'o i ai ni faiga tuai o le a latou tauaveina le maualuga o tau fa'atonutonuina o le filogia ma le fa'atonuga fa'atonutonu, ma o kamupani fa'aleaganu'u fa'aleaganu'u o lo'o fa'atupuina le maualuga o le filogia, maualuga le fa'aaogaina o le malosi ma mea e maualalo le tau-fa'aopoopo (eg penicillin, vitamini, ma isi) o le a feagai ma le fa'avavevave fa'aumatia. O le pipii atu i le faagasologa o mea fou ma le atinaʻeina o tekonolosi vailaʻau lanumeamata ua avea ma taʻiala o le atinaʻe i le lumanaʻi o falemaʻi CMO.

4. O lo'o lisiina pisinisi fa'atauva'a fa'alotoifale
Mai le tulaga o le alamanuia filifili, o le 6 lisi o kamupani o vailaau lelei e gaosia vailaʻau vailaʻau o loʻo i ai uma i le pito i lalo ole filifili alamanuia. Pe fa'apolofesa 'au'aunaga tu'uina atu i fafo po'o le API ma fa'aopoopo fa'aopoopo, malosi fa'atekinisi o le malosi fa'aola lea.
I le tulaga o le malosi faatekonolosi, kamupani o loʻo i ai tekonolosi i tulaga taʻutaʻua faʻavaomalo, malosi faʻaagaaga malosi ma maualuga tupe teufaafaigaluega i R&D e faʻamanuiaina.
Vaega I: Lianhua Technology ma Arbonne Chemical. Lianhua Tekonolosi e valu tekinolosi autu e pei o le ammonia oxidation ma fluorination o lona autu faatekinolosi, lea o le hydrogen oxidation o loʻo i le tulaga taʻutaʻua faavaomalo. Abenomics o se taʻitaʻi faʻavaomalo i vailaʻau faʻamaʻi, aemaise lava i ana vailaʻau vaevaega ma tekinolosi faʻasolosolo, ma o loʻo i ai le maualuga o le R&D tupe teufaafaigaluega, e tusa ma le 6.4% o tupe maua.
Vaega II: Wanchang Technology ma Yongtai Technology. Wanchang Technology's waste gas hydrocyanic acid method o le tau maualalo ma sili ona alualu i luma faiga mo le gaosiga o esters acid prototrizoic. O Yongtai Technology, i le isi itu, ua lauiloa mo ana vailaʻau lelei o le fluorine.
Vaega III: Tianma Fine Chemical ma Bikang (na taʻua muamua o Jiuzhang).
Fa'atusatusaga o le malosi fa'atekinisi o kamupani lisiina
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Fa'atusatusaga o tagata fa'atau ma fa'ata'ita'iga fa'atauga o kamupani fa'alaua'itele vaila'au lisiina
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Fa'atusatusaga o mana'oga i lalo ma le taamilosaga ola pateni o oloa a kamupani ua lisiina
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Iloiloga o oloa faatauva a kamupani lisiina
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Ole auala ile fa'aleleia ole vaila'au fa'agata
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(Ata ma mea mai le Qilu Securities)
Fa'amoemoega o atina'e o pisinisi fa'alaua'itele a Saina
I le avea ai o se alamanuia taua i le fanua o alamanuia kemisi lelei, gaosiga o vailaau faafomai ua avea ma taulaiga o atinae ma tauvaga i le 10 tausaga talu ai, faatasi ai ma le alualu i luma o le faasaienisi ma tekinolosi, e tele vailaau ua atiina ae faifai pea mo le manuia o tagata, o le tuufaatasia. o nei vailaʻau e faʻalagolago i le gaosiga o vailaʻau fou, maualuga maualuga, o lea e puipuia ai vailaʻau fou e pateni, ae o loʻo i ai faʻatasi ma i latou e leai ni faʻafitauli, o le mea lea, o le vailaʻau fou e fesoʻotaʻi i totonu o le fale ma fafo O le atinaʻeina o maketi avanoa ma le faʻamoemoega o talosaga. e matua folafola.
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I le taimi nei, o le suʻesuʻega o suʻesuʻega o vailaʻau faʻasaina e masani lava ona atagia i le faʻaogaina o vailaʻau heterocyclic, fluorine-containing compounds, chiral compounds, biological compounds, ma isi. i Saina. O nisi o oloa e maualuga tulaga faʻapitoa e le mafai ona faʻatulagaina mo le gaosiga i Saina ma faʻalagolago i le faʻaulufale mai, e pei o le piperazine anhydrous, propionic acid, ma isi. tau ma le lelei e le oʻo i tulaga masani, lea e aʻafia ai le faʻatauvaʻa o vailaʻau ma manaʻomia le faʻaleleia o le gaosiga o gaosiga, e pei o le TMB, p-aminophenol, D-PHPG, ma isi.
O loʻo faʻamoemoeina i nai tausaga o lumanaʻi, o le a taulaʻi suʻesuʻega fou a le lalolagi i vaega nei e 10 o vailaʻau: vailaʻau faʻaleleia o le faiʻai, vailaʻau faʻamaʻi faʻamaʻi, vailaʻau faʻamaʻi AIDS, faʻamaʻi hepatitis ma isi vailaʻau viral, lipid. -tuuina atu fualaau faasaina, anti-thrombotic fualaau, vailaau anti-tumour, platelet-activating factor antagonists, glycoside cardiac stimulants, antidepressants, anti-psychotic ma anti-popole vailaau, ma isi. atina'e o vaila'au vavalo ma se auala taua e fa'alautele avanoa fou maketi.