MIT-Ivy Alamanuia o se pharmaceutical ma vailaʻau vaeluaga atinaʻe tuʻufaʻatasia le gaosiga, faʻatau ma suʻesuʻega faʻasaienisi. Faatasi ai ma le gaosiga o masini gaosiga ma tekinolosi gaosiga, matou te tausia lelei sootaga vavalalata ma faʻalapotopotoga suʻesuʻe faasaienisi ma iunivesite tetele ma feololo. O loʻo matou galulue faʻatasi i le gaosiga ma le faʻatau atu o se faasologa o vailaʻau faʻapitoa, aemaise lava i le togafitiga o vailaʻau faʻamaʻi, cardiovascular ma cerebrovascular, ma le lagolagoina o vailaʻau faʻamaʻi. O oloa o le sodium azide, triphenyl chloromethane, L- valine methyl ester hydrochloride o lo'o fa'atauina ile fale ma fafo.1. Fa'atomuaga o vaila'au fa'alaua'itele Fa'ata'ita'i vaila'au fa'atatau i oloa fa'atauva'a e pei o mea mata'utia, meafaitino ma mea fa'apitoa e fa'aaogaina i le gaosiga o vaila'au fa'apitoa. ma vaila'au malosi e mana'omia le talia o le GMP fa'amaonia. O vaila'au fa'atauva'a, e ui ina fa'aaogaina i le gaosiga o vaila'au, e na'o le tu'ufa'atasiga ma le gaosiga o vaila'au mata'utia. O i latou o oloa sili ona taua ma pito i lalo i le gaosiga o fualaau faasaina ma e le mafai ona taʻua o vailaʻau, o lea e le manaʻomia ai le GMP faʻamaonia. E mafai ona gaosia mea tau vailaʻau i vailaʻau faʻapitoa masani ma e mafai ona faʻaaogaina i le tuʻufaʻatasiga o vailaʻau faʻapitoa i nisi tulaga. fa'aiti'itia fo'i le fa'aulufaleina o le alamanuia mo tagata fa'atauva'a.O le ata2. Fua o alamanuia intermediates pharmaceuticalMa le fetuunaiga o fausaga alamanuia, transnational fesiitaiga gaosiga ma le toe faaleleia atili o le faava o malo vaevaega o galuega a tele multinational pharmaceutical kamupani, Saina ua avea o se tulaga taua tele gaosiga i le lalolagi vaevaega o galuega o alamanuia tau vailaau. Lipoti i luga o le Atinaʻeina o Falemaʻi Intermediates Alamanuia a Saina (2016), mai le 2011 i le 2015, Saina alamanuia intermediates vailaau ma lona tau aofaʻi o oloa faʻatupulaia i lea tausaga ma lea tausaga, faʻatasi ai ma le fua faʻatatau o le tuputupu aʻe faʻaletausaga e tusa ma le 13.5%. o vailaʻau vaʻaia i Saina na oʻo atu i le 422.56 piliona yuan i le 2015, o se faʻaopoopoga o le 9.88% i lea tausaga ma lea tausaga. Na oʻo atu i le 17.2 miliona tone le gaosiga o pisinisi, i luga ole 10.26 pasene i le tausaga. yuan i le 2020.O le ata3. O uiga faʻapisinisi o vailaʻau faʻatauvaʻaO loʻo manaʻomia faʻanatinati le alamanuia mo le faʻaleleia ma le faʻaleleia: O le tulaga faʻatekonolosi atoa a Saina o loʻo maualalo pea, ma o loʻo i ai ni nai atinaʻe o loʻo gaosia se numera tele o vailaʻau faʻapitoa ma lagolago mo vailaʻau fou pateni, o loʻo i le atinaʻe. tulaga o le fausaga o oloa optimization ma le faʻaleleia.Naʻo nisi atinaʻe ma suʻesuʻega malosi ma atinaʻe malosi, fale gaosiga faʻalauteleina ma le tele o le gaosiga o le poto masani e mafai ona maua ni tupe maua maualuga i le tauvaga. fa'ata'ita'iga pisinisi. I lalo o le faʻataʻitaʻiga faʻapitoa faʻataʻitaʻiga, o le felagolagomai sootaga i le va o tagata faʻatau tetele ma tagata faʻatau oloa e matua mausali, ma o le vavalalata o le galulue faʻatasi, o le maualuga o le faʻalagolago, ma le tele o vaega galulue faʻatasi e tuʻuina atu e tagata faʻatau tele o le a. fa'atau oloa. O le mea lea, i le avea ai o se pisinisi ma le malosi pipii, pharmaceutical intermediates alamanuia pisinisi e tele lava ina taulaʻi atu i luga o taʻutaʻua pisinisi mai fafo pharmaceutical i le taimi nei stage.Once le kamupani na ulu atu i le faiga autu o le tuuina atu o vailaau faafomai, e le gata i le fua o le gaosiga ma le tupe faasili tupe faasili tausia se tulaga mautu tulaga.Low-iuga auina atu i fafo e masani lava: o le autu auina atu i fafo itulagi o pharmaceutical intermediates i Saina o le EU, Amerika i Matu, Sasaʻe Tutotonu, Southeast Asia, ma isi. O le auina atu i fafo o lo tatou atunuu e masani ona taulai i vitamini C, penicillin, acetaminophen, acid citric. ma ona masima ma esters, e pei o oloa, o uiga o oloa o le gaosiga o oloa, gaosiga o pisinisi, o le tauvaga maketi e malosi, tau o oloa ma le tau faaopoopo e maualalo, o le tele o gaosiga o latou na mafua ai le tulaga o le tele o oloa gaosi oloa. High-tech oloa o loʻo faʻaulufaleina mai lava. Atinaʻe laiti ma feololo: o pisinisi gaosiga o le tele o pisinisi tumaoti, faʻaogaina fetuutuunai, e le tele le faʻatupeina o tupe, faʻavae i le va o le miliona i le sefulu poʻo le luasefulu miliona yuan.Regional concentration: o le tufatufaina faʻaitulagi o o pisinisi gaosiga o loʻo faʻapitoa, faʻataʻamilo i le tele o fale gaosi oloa, e masani ona tufatufaina i Taizhou, Zhejiang ma Jintan, Jiangsu o le totonugalemu o le itulagi.Zhejiang Huangyan, Taizhou, Nanjing Jintan, Shijiazhuang, Jinan (e aofia ai Zibo), i matu sasaʻe (Siping, Fushun). ) ma isi vaega o loʻo i ai tulaga lelei mo le atinaʻeina o vailaʻau faʻatauvaʻa ua atiaʻe faʻapitoa vave. Faʻafouina oloa vave: o se oloa e masani lava i luga o le maketi 3 i le 5 tausaga mulimuli ane, o lona fua faatatau o tupe mama o le a pa'ū tele, lea e faʻamalosia ai pisinisi e faʻaauau pea ona atiaʻe oloa fou. poʻo le faʻaleleia pea o le gaosiga o le gaosiga, ina ia faʻatumauina ai le maualuga o le gaosiga. O pisinisi kemikolo e auai i le gaosiga o vaila'au fa'alaua'itele, e o'o atu ai i le fa'atupula'ia o le fa'atupu fa'alavelave fa'aletonu i totonu o pisinisi.4. Ituaiga o vailaʻau vailaʻau e tele ituaiga o vailaʻau faʻapitoa, e aofia ai le cephalosporin intermediates, amino acid protectant series, vitamin intermediates, quinolone intermediates, ma isi ituaiga o intermediates, e pei o vailaʻau faʻamaʻi faʻamaʻi, vailaʻau antiepileptic intermediates, fluoropyridine intermediates intermediates ma isi mea faapena. .E tusa ai ma a latou fanua talosaga, e mafai ona vaevaeina i latou i vailaau antibiotic intermediates, antipyretic ma analgesic fualaau faasaina intermediates, cardiovascular system fualaau faasaina intermediates, anti-kanesa fualaau faasaina intermediates ma isi. I le taimi nei, e tusa ma le selau o vailaau intermediates oloa, ma i taimi uma. innovate, fausia le tele o alamanuia molecular lelei i le alamanuia intermediates pharmaceutical.E tele ituaiga o vailaau faapitoa intermediates.E pei o imidazole, furan, phenolic intermediates, aromatic intermediates, pyrrole, pyridine, biochemical reagents, sulfur, nitrogen, halogen compounds, heterocyclic compounds , microcrystalline cellulose, starch, mannitol, lactose, dextrin, ethylene glycol, suka paʻu, salts inorganic, ethanol intermediates, stearic acid, amino acid ma ethanol amine salt, sylvite, sodium salt ma isi intermediates ma isi.O le ata5. Patent CliffTalu mai le 2000, o loʻo faʻaauau pea ona tupu vave le maketi o vailaʻau faʻavaomalo nai lo le maketi atoa o vailaʻau, faʻatupulaia e sili atu nai lo le faaluaina vave nai lo vailaʻau pateni. maketi fualaau faasaina mai le 2005 i le 2013 ua faamoemoe e oo atu i le 14.7%.O le maketi lautele o le lalolagi ua faamoemoe e tupu i le 10% i le 14% i luga o le isi lima tausaga, e sili atu le vave nai lo le faamoemoe 4% i le 6% tuputupu aʻe mo le alamanuia pharmaceutical atoa. E mafai ona faʻapea o le atinaʻeina o maketi vailaʻau lautele o le a mautinoa lava le faʻalauiloaina o le atinaʻeina o vailaʻau vaʻaia vaʻaia. o le lalolagi Patent expiration varieties o le a sili atu nai lo le 200 i tausaga taʻitasi, lea e taʻua o le "Patent Cliff" i le lalolagi. I le 2014, o le ai ai se tumutumu o le faʻaaogaina o fualaau faasaina, lea o le ai ai se tumutumu i le 2014, ma e 326 le aofa'i o vaila'au pateni ua mae'a. O le 2010 ma le 2017 o tausaga maualuga ia e lua, faatasi ai ma le 205 ma le 242 pateni fualaau faasaina ua maeʻa. O vailaʻau ua maeʻa o le tele lava o faʻamaʻi pipisi, endocrine, nervous system ma cardiovascular drugs, faʻatasi ai ma le tele o le maketi tele. vaila'au, o le gaosiga o vaila'au fa'apitoa e feso'ota'i o le a pa, lea o le a fa'ateleina ai le fa'atupulaia vave o le mana'oga mo vaila'au fa'afeso'ota'i feso'ota'i. O le ata6. Siosiomaga pressure ua uma ona avea Saina o se tagata faatau atu tele o API intermediates, faapea foi ma se polluter.Pharmaceutical intermediate gaosi oloa e auai i alamanuia kemisi lelei, o le ai ai tulaga filogia talafeagai. E tusa ai ma fuainumera mai le Matagaluega o le Puipuiga o le Siosiomaga, o le aofaʻiga o le tau o le gaosiga o le alamanuia tau vailaau i totonu o le atunuu e itiiti ifo i le 3 pasene o le GDP o le atunuu, ae o le aofaiga atoa o emissions filogia e oo atu i le 6 pasene. I totonu o ituaiga uma o fualaau faasaina, o le API e masani ona fai ma sui o vitamini ma penicillin e patino i le alamanuia o le filogia maualuga ma le taumafaina malosi maualuga, lea e faʻaleagaina ai le ea ma le vai aemaise lava faʻapitoa. E tusa ai ma le tuʻufaʻatasia o le Matagaluega o le Puipuiga o le Siosiomaga, i le aso 15 o Fepuari, 2017, o le au asiasi faapitoa mo le lelei o le ea i le kuata muamua o le 2017 na faasilasila mai e le o le faʻauluina o le mamafa i Shijiazhuang. i le nofoaga, ma o le itumalo-tulaga malo sa masani lava ona faavae i luga o le Ofisa o le Puipuiga o le Siosiomaga tagata faigaluega i le faatinoga o le tau filogia mamafa fuafuaga faalavelave faafuasei, ae o isi matagaluega sa le aafia i se tikeri maualuga. O le filogia o pisinisi laiti ma feololo. gaosia intermediates pharmaceutical i Shijiazhuang e serious.Pharmaceutical pisinisi ma tekinolosi i tua o le a tauaveina le maualuga o le pulea o le filogia ma le mamafa o tulafono faatonutonu, ma pisinisi tau vailaau masani e masani lava ona gaosia le filogia maualuga, maualuga le taumafaina malosi ma oloa maualalo tau-faaopoopo (e pei o penicillin, vitamini, ma isi. ) o le a feagai ma faʻavaveina elimination.Adhering to process innovation and development green pharmaceutical technology has become the future development direction of pharmaceutical intermediates industry.The ata
7. Taitai o pisinisi
alamanuia mit-ivy
Zhejiang NHU Kamupani Ltd.Plo Co., Ltd
Lianhe Chemical Technology Co., Ltd.Anhui Bayi Chemical Co. LtdZhejiang Huahai Pharmaceutical Co. LtdZhejiang Hisoar Pharmaceutical Co., Ltd.Jiangsu Jiujiu Technology Co., LtdFederal pharmaceutical (chengdu) co., LTDZhejiang Yongtai Technology Co., Ltd.Suzhou Tianma Specialty Chemicals Co.,Ltd.